Neuroleptic malignant syndrome (NMS): clinical features

Evidence-based neurology checklist on neuroleptic malignant syndrome (nms): clinical features: Pathophysiology of NMS The use or withdrawal of both classical and atypical neuroleptics The use of dopamine-depleting drugs The withdrawal of dopaminergic drugs Onset features Main neurological features…

Pathophysiology of NMS

  • The use or withdrawal of both classical and atypical neuroleptics
  • The use of dopamine-depleting drugs
  • The withdrawal of dopaminergic drugs

Onset features

Main neurological features

Autonomic features

Other neurological features

Differential diagnosis

References

  1. Adnet P, Lestavel P, Krivosic-Horber R. Neuroleptic malignant syndrome. Br J Anaesth 2000; 85:129-135.
  2. Munhoz RP, Moscovich M, Araujo PD, Tieve HAG. Movement disorders emergencies: a review. Arq Neuropsiquiatr 2012; 70:453-461.
  3. Adnet P, Lestavel P, Krivosic-Horber R. Neuroleptic malignant syndrome. Br J Anaesth 2000; 85:129-135.
  4. Ong KC, Chew EL, Ong YY. Neuroleptic malignant syndrome without neuroleptics. Singapore Med J 2001; 42:85-88.
  5. Lee S, Merriam A, Kim T-S, Liebling M, Dickson DW, Moore GRW. Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury. JNNP 1989; 52:387-391.
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