Nerve biopsy

Evidence-based neurology checklist on nerve biopsy: Strong indications Vasculitic neuropathy with no extra-neural involvement Pure neuritic leprosy Primary nerve sheath tumours Neurolymphomatosis Moderate indications Unimportant indications Diagnostic outcomes Diagnostic yield Complications Acronym

Strong indications

  • Vasculitic neuropathy with no extra-neural involvement
  • Pure neuritic leprosy
  • Primary nerve sheath tumours
  • Neurolymphomatosis

Moderate indications

Unimportant indications

Diagnostic outcomes

Diagnostic yield

Complications

Acronym

References

  1. Nathani D, Spies J, Barnett MH, et al. Nerve biopsy: current indications and decision tools. Muscle Nerve 2021; 64:125-139.
  2. England JD, Gronseth GS, Franklin G, et al. Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology 2009; 72:177-184.
  3. Alport AR, Sander HW. Clinical approach to peripheral neuropathy: anatomic localization and diagnostic testing. Continuum (Minneap Minn) 2012; 18:13-38.
  4. Said G. Indications and usefulness of nerve biopsy. Arch Neurol 2002; 59:1532-1535.
  5. Chia L, Fernandez A, Lacroix C, Adams D, Planté V, Said G. Contribution of nerve biopsy findings to the diagnosis of disabling neuropathy in the elderly. A retrospective review of 100 consecutive patients. Brain 1996; 119:1091-1098.
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