Motor predominant peripheral neuropathy
Evidence-based neurology checklist on motor predominant peripheral neuropathy: Hereditary causes Motor neurone disease (MND) Spinal muscular atrophies (SMA) Spinal and bulbar muscular atrophy (SBMA, Kennedy’s disease) Distal hereditary motor neuropathies (dHMNs) Porphyria PIGG recessive variants…
Hereditary causes
- Motor neurone disease (MND)
- Spinal muscular atrophies (SMA)
- Spinal and bulbar muscular atrophy (SBMA, Kennedy’s disease)
- Distal hereditary motor neuropathies (dHMNs)
- Porphyria
- PIGG recessive variants
Sporadic causes
Infectious causes
Drug induced
Immune-mediated
Other causes
References
- Garg N, Park SB, Vucic S, et al. Differentiating lower motor neuron syndromes. JNNP 2017; 88:474-483.
- Verschueren A. Motor neuropathies and lower motor neuron syndromes. Rev Neurol (Paris) 2017; 173:320-325.
- Alport AR, Sander HW. Clinical approach to peripheral neuropathy: anatomic localization and diagnostic testing. Continuum (Minneap Minn) 2012; 18:13-38.
- Willison HJ, Winer JB. Clinical evaluation and investigation of neuropathy. JNNP 2003; 74(Suppl II):ii3-ii8.
- Record CJ, O'Connor A, Verbeek NE, et al. Recessive variants in PIGG cause a motor neuropathy with variable conduction block, childhood tremor, and febrile seizures: expanding the phenotype. Ann Neurol 2025; 97:388-396.
Related checklists
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- Autonomic dominant peripheral neuropathy
- Non-length dependent peripheral neuropathy
- Relapsing peripheral neuropathy
- Hereditary peripheral neuropathy: causes
- Hereditary disorders with associated neuropathy
- Acute onset peripheral neuropathy
- Painful peripheral neuropathy
- Upper limb onset peripheral neuropathy
- Ulcerating peripheral neuropathy
- Ominous peripheral neuropathy
