Motor neurone disease (MND): protective factors
Evidence-based neurology checklist on motor neurone disease (mnd): protective factors: Possible protective factors Vitamin E therapy Chemotherapy Diabetes: especially late onset age Oral contraceptives Hormone replacement therapy (HRT) Methylene chloride Statins Non-risk factors
Possible protective factors
- Vitamin E therapy
- Chemotherapy
- Diabetes: especially late onset age
- Oral contraceptives
- Hormone replacement therapy (HRT)
- Methylene chloride
- Statins
Non-risk factors
References
- Wang H, O'Reilly EJ, Weisskopf MG, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis: a polled analysis of data from 5 prospective cohort studies. Am J Epidemiol 2011; 173:595-602.
- Kuczmarski T, Stommel EW, Riley K, et al. Medical history of chemotherapy or immunosuppressive drug treatment and risk of amyotrophic lateral sclerosis (ALS). J Neurol 2017; 264:1763-1767.
- D'Ovidio F, d'Errico A, Carnà P, Calvo A, Costa G, Chiò A. The role of pre-morbid diabetes on developing amyotrophic lateral sclerosis. Eur J Neurol 2018 25:164-170.
- Tsai CP, Lee JK, Lee CT. Type II diabetes mellitus and the incidence of amyotrophic lateral sclerosis. J Neurol 2019; 266:2233-2243.
- Rooney JPK, Visser AE, D'Ovidio F, et al; Euro-MOTOR Consortium. A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR. Neurology 2017; 89:1283-1290.
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