Motor neurone disease (MND): blood tests
Evidence-based neurology checklist on motor neurone disease (mnd): blood tests: Basic investigations Routine blood tests C-reactive protein (CRP) Glucose Syphilis screen (VDRL) Electrophoresis Thyroid function tests (TFT) Creatinine kinase (CK) Baseline respiratory function Genetic tests Other…
Basic investigations
- Routine blood tests
- C-reactive protein (CRP)
- Glucose
- Syphilis screen (VDRL)
- Electrophoresis
- Thyroid function tests (TFT)
- Creatinine kinase (CK)
- Baseline respiratory function
Genetic tests
Other blood tests
Neurofilament light chain (NfL)
References
- Wood-Allum C, Shaw PJ. Motor neurone disease: a practical update on diagnosis and management. Clin Med 2010; 10:252-258.
- Baek WS, Desai NP. ALS: pitfalls in the diagnosis. Pract Neurol 2007; 7:74-81.
- Gaiani A, Martinelli I, Bello L, et al. Diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis: neurofilament light chain levels in definite subtypes of disease. JAMA Neurol 2017; 74:525-532.
- Verde F, Steinacker P, Weishaupt JH, et al. Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis. JNNP 2019; 90:157-164.
- McCluskey G, Morrison KE, Donaghy C, et al. Serum neurofilaments in motor neuron disease and their utility in differentiating ALS, PMA and PLS. Life (Basel) 2023; 13:1301.
