Migraine: analgesics and anti-emetics

Non-steroidal anti-inflammatory drugs (NSAIDs)

• Ibuprofen 400-600mg PO
• Naproxen 750-825mg PO
• Diclofenac Potassium 50-100mg PO
• Diclofenac 100mg suppository
• Combination with triptans e.g. Sumatriptan and Naproxen

Analgesics

Anti-emetics: Prochlorperazine

Anti-emetics: others

Other acute intravenous (IV) treatments

Acronyms

References

1. Marmura MJ. Use of dopamine antagonists in treatment of migraine. Curr Treat Options Neurol 2012; 14:27-35.
2. Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force. Eur J Neurol 2009; 16:968-981.
3. Gelfand AA, Goadsby PJ. A neurologist's guide to acute migraine therapy in the emergency room. The Neurohospitalist 2012; 2:51-59.
4. MacGregor EA, Steiner TJ, Davies PTG. British Association for the Study of Headaches (BASH). Guidelines for all healthcare professionals in the diagnosis and management of migraine, tension-type, cluster and medication-overuse headache. September 2010.
5. Wilcha RJ, Afridi SK, Barbanti P, et al. Sumatriptan-naproxen sodium in migraine: a review. Eur J Neurol 2024; 31(Suppl 2):e16434.
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Related checklists

• Migraine non-drug treatment options
• Lasmiditan (withdrawn)