Mast cell activation syndrome (MCAS): pathology

Evidence-based neurology checklist on mast cell activation syndrome (mcas): pathology: Pathology This comprises all disorders caused by mast cell activation It manifests as systemic anaphylaxis involving at least two organ systems The pathology results from mast cell mediators and their…

Pathology

  • This comprises all disorders caused by mast cell activation
  • It manifests as systemic anaphylaxis involving at least two organ systems
  • The pathology results from mast cell mediators and their metabolites
  • It presents with episodic symptoms

MCAS mediators and metabolites

Classification

Primary MCAS: types

References

  1. Weiler CR, Austen KF, Akin C, et al. AAAAI Mast Cell Disorders Committee Work Group Report: mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol 2019; 144:883-896. 
  2. Frieri M. Mast cell activation syndrome. Clin Rev Allergy Immunol 2018; 54:353-365.

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