Manganism
Evidence-based neurology checklist on manganism: Pathology This results from manganese toxicity There is elevated manganese in the serum and cerebrospinal fluid (CSF) Genetic causes Acquired causes Manganese-associated disorders Clinical features: movement disorders Clinical features: others…
Pathology
- This results from manganese toxicity
- There is elevated manganese in the serum and cerebrospinal fluid (CSF)
Genetic causes
Acquired causes
Manganese-associated disorders
Clinical features: movement disorders
Clinical features: others
Differential diagnosis
Magnetic resonance imaging (MRI) brain: features
DaT scan
Treatment
References
- Budinger D, Barral S, Soo AKS, Kurian MA. The role of manganese dysregulation in neurological disease: emerging evidence. Lancet Neurol 2021; 20:956-968.
- Proudfoot O. Manganese in manganism, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease: A narrative review. Neurol India 2017; 65:1241-1247.
- Ghosh R, Dubey S, Chatterjee S, Ghosh M, Ray BK, Benito-León J. Hypermanganesemia induced chorea and cognitive decline in a tea seller. Tremor Other Hyperkinet Mov (N Y) 2020; 10:45.
- Kulshreshtha D, Ganguly J, Jog M. Manganese and movement disorders: a review. J Mov Disord 2021; 14:93-102.
- Alikunju M, Misiriyyah N, Sayeed Iqbal S, Khan M. Manganese neurotoxicity as a stroke mimic: a case report. Cureus 2023; 15:e37247.
