Lyme neuroborreliosis: investigations

Evidence-based neurology checklist on lyme neuroborreliosis: investigations: Serology Seroconversion: this is a 4X rise of anti-Borrelia burgdorferi antibodies Microbiology Cerebrospinal fluid (CSF) analysis Magnetic resonance imaging (MRI)

Serology

  • Seroconversion: this is a 4X rise of anti-Borrelia burgdorferi antibodies 

Microbiology

Cerebrospinal fluid (CSF) analysis

Magnetic resonance imaging (MRI)

References

  1. Prasad A, Sankar D. Overdiagnosis and overtreatment of Lyme neuroborreliosis are preventable. Postgrad Med J 1999; 75:650-656.
  2. Djukic M, Schmidt-Samoa C, Lange P, Spreer A, Neubieser K, Eiffert H, Nau R, Schmidt H. Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis. J Neurol 2012; 259:630-636.
  3. Pietikäinen A, Oksi J, Hytönen J. Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagn Microbiol Infect Dis 2018; pii: S0732-8893(18)30072-5. 
  4. Henningsson AJ, Gyllemark P, Lager M, Skogman BH, Tjernberg I. Evaluation of two assays for CXCL13 analysis in cerebrospinal fluid for laboratory diagnosis of Lyme neuroborreliosis. APMIS 2016; 124:985-990. 
  5. Barstad B, Tveitnes D, Noraas S, et al. Cerebrospinal fluid B-lymphocyte chemoattractant CXCL13 in the diagnosis of acute lyme neuroborreliosis in children. Pediatr Infect Dis J. 2017 Dec;36(12):e286-e292.
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