Limbic predominant age related TDP-43 encephalopathy (LATE): diagnostic criteria

Evidence-based neurology checklist on limbic predominant age related tdp-43 encephalopathy (late): diagnostic criteria: Clinical criteria Age of onset >75 years A primary amnestic syndrome with temporo-limbic memory loss There may be mild semantic memory impairment Sparing of other cognitive…

Clinical criteria

  • Age of onset >75 years
  • A primary amnestic syndrome with temporo-limbic memory loss
  • There may be mild semantic memory impairment
  • Sparing of other cognitive functions until later
  • It runs an indolent course over >2 years

Radiological criteria

Supportive tests

References

  1. Wolk DA, Nelson PT, Apostolova L, et al. Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy. Alzheimers Dement 2025 (Online ahead of print).

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