Lhermitte Duclos disease (LDD)

Pathology

• This is a dysplastic gangliocytoma of the cerebellum
• It is a complex hamartoma
• It may be bilateral

Pathological features

Associated disorders

Clinical features

Magnetic resonance imaging (MRI)

Magnetic resonance spectroscopy (MRS)

Positron emission tomography (PET) scan

Treatment

References

1. Somagawa C, Ono T, Honda R, et al. Frequent vomiting attacks in a patient with Lhermitte-Duclos disease: a rare pathophysiology of cerebellar lesions? J Neurosurg Pediatr 2017; 20:298-301.
2. Andres RH, Guzman R, Weis J, Brekenfeld C, Fandino J, Seiler RW. Lhermitte-Duclos disease with atypical vascularization-case report and review of the literature. Clin Neuropathol 2009; 28:83-90.
3. Bozbuga M, Gulec I, Suslu HT, Bayindir C. Bilateral Lhermitte-Duclos disease. Neurol India 2010; 58:309-311.
4. Yağci-Küpeli B, Oguz KK, Bilen MA, Yalçin B, Akalan N, Büyükpamukçu M. An unusual cause of posterior fossa mass: Lhermitte-Duclos disease. J Neurol Sci 2010; 290:138-141. 
5. Dutta G, Singh D, Saran RK, Singh H, Srivastava AK, Jagetia A. Childhood Lhermitte-Duclos disease progressing to medulloblastoma in bilateral cerebellar hemispheres: report of unusual case. World Neurosurg 2018; 117:344-349. 
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