Levetiracetam: adverse effects

Evidence-based neurology checklist on levetiracetam: adverse effects: Teratogenicity There is a 0.7% risk of major congenital malformation (MCM) The risk is higher with concomitant Valproate or Carbamazepine The risk is less with concomitant Lamotrigine Neuropsychiatric adverse events (NSAEs)…

Teratogenicity

  • There is a 0.7% risk of major congenital malformation (MCM)
  • The risk is higher with concomitant Valproate or Carbamazepine
  • The risk is less with concomitant Lamotrigine

Neuropsychiatric adverse events (NSAEs)

Neurological side effects

Systemic side effects

References

  1. Abou-Khalil B. Levetiracetam in the treatment of epilepsy. Neuropsychiatr Dis Treat 2008; 4:507-523.
  2. Mawhinney E, Craig J, Morrow J, et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology 2013; 80:400-405. 
  3. Fujikawa M, Kishimoto Y, Kakisaka Y, et al. Obsessive-compulsive behavior induced by levetiracetam. J Child Neurol 2015; 30:942-944. 
  4. Chen Z, Lusicic A, O'Brien TJ, Velakoulis D, Adams SJ, Kwan P. Psychotic disorders induced by antiepileptic drugs in people with epilepsy. Brain 2016; 139:2668-2678. 
  5. Molokwu OA, Ezeala-Adikaibe BA, Onwuekwe IO. Levetiracetam-induced rage and suicidality: two case reports and review of literature. Epilepsy Behav Case Rep 2015; 4:79-81.
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