Lesch-Nyhan syndrome: treatment
Evidence-based neurology checklist on lesch-nyhan syndrome: treatment: Treatments to prevent self-injury Behavioural therapy S-adenosylmethionine (SAMe) Physical restraints Intraoral appliances Botulinum toxin Tooth extraction Deep brain stimulation (DBS) Treatment to reduce uric acid level:…
Treatments to prevent self-injury
- Behavioural therapy
- S-adenosylmethionine (SAMe)
- Physical restraints
- Intraoral appliances
- Botulinum toxin
- Tooth extraction
- Deep brain stimulation (DBS)
Treatment to reduce uric acid level: Allopurinol
Other treatments
References
- Ferrão J, Rodrigues Barros C, Figueiredo L, Fernandes A. Oral self-mutilation in Lesch-Nyhan syndrome: a case report. Cureus 2022; 14:e27874.
- Hull M, Parnes M, Jankovic J. Botulinum neurotoxin injections in children with self-injurious behaviors. Toxins (Basel) 2023; 15:236.
- Torres RJ, Puig JG. Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome. Orphanet J Rare Dis 2007; 2:48.
- Satow T, Ogawa M, Komuro T. Intrathecal baclofen therapy for Lesch-Nyhan disease: illustrative case. J Neurosurg Case Lessons 2021; 1:CASE202.
