Late onset Friedreich’s ataxia (LOFA)
Evidence-based neurology checklist on late onset friedreich’s ataxia (lofa): FA onset age definitions Classical onset age: the onset age is <20 years Very young onset age: this is associated with p.C282Y heterozygosity Late-onset Friedreich’s ataxia (LOFA): the onset age is > 25 years Very late…
FA onset age definitions
- Classical onset age: the onset age is <20 years
- Very young onset age: this is associated with p.C282Y heterozygosity
- Late-onset Friedreich’s ataxia (LOFA): the onset age is > 25 years
- Very late onset Friedreich’s ataxia (VLOFA): the onset age is >40 years
Features more frequent in LOFA
Features less frequent in LOFA: neurological
Features less frequent in LOFA: systemic
References
- Lecocq C, Charles P, Azulay JP, et al. Delayed-onset Friedreich's ataxia revisited. Mov Disord 2016; 31:62-69.
- Koppel AH. Friedreich's ataxia: pathology, pathogenesis, and molecular genetics. J Neurol Sci 2011; 303:1-12.
- Martinez AR, Moro A, Abrahao A, et al. Nonneurological involvement in late-onset Friedreich ataxia (LOFA): exploring the phenotypes. Cerebellum 2017; 16:253-256.
- Fearon C, Lonergan R, Ferguson D, Byrne S, Bradley D, Langan Y, Redmond J. Very-late-onset Friedreich's ataxia: diagnosis in a kindred with late-onset cerebellar ataxia. Pract Neurol 2020; 20:55-58.
- Vidhale TA, Gupta HR, Pj R, Gandhi C. Very late-onset Friedreich's ataxia with rapid course mimicking as possible multiple system atrophy cerebellar type. BMJ Case Rep 2021; 14:e242073.
- And 7 more. Subscribe to see the full list
