Lamotrigine: adverse effects
Evidence-based neurology checklist on lamotrigine: adverse effects: Teratogenic malformation types Spina bifida Anencephaly Transposition of the great arteries Contradictory reports of the risk of cleft lip and palate Dermatological side effects Neuropsychiatric side effects Movement disorders…
Teratogenic malformation types
- Spina bifida
- Anencephaly
- Transposition of the great arteries
- Contradictory reports of the risk of cleft lip and palate
Dermatological side effects
Neuropsychiatric side effects
Movement disorders
Systemic side effects
References
- de Jong J, Garne E, de Jong-van den Berg LT, Wang H. The risk of specific congenital anomalies in relation to newer antiepileptic drugs: a literature review. Drugs Real World Outcomes 2016; 3:131-143.
- Jentink J, Dolk H, Loane MA, et al; EUROCAT Antiepileptic Study Working Group. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ 2010; 341:c6581.
- Verrotti A, Mencaroni E, Castagnino M, Zaccara G. Foetal safety of old and new antiepileptic drugs. Expert Opin Drug Saf 2015; 14:1563-1571.
- Holmes LB, Baldwin EJ, Smith CR, et al. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2008; 70:2152-2158.
- Dolk H, Jentink J, Loane M, Morris J, de Jong-van den Berg LT; EUROCAT Antiepileptic Drug Working Group. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 2008; 71:714-722.
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