Lambert Eaton myasthenic syndrome (LEMS): causes

Evidence-based neurology checklist on lambert eaton myasthenic syndrome (lems): causes: Small cell lung cancer (SCLC) This is more frequent in older patients It is predicted by the absence of the HLA-B8 haplotype SOX1 antibody is a marker of SCLC in LEMS SOX1 can be also used in cancer…

Small cell lung cancer (SCLC)

  • This is more frequent in older patients
  • It is predicted by the absence of the HLA-B8 haplotype
  • SOX1 antibody is a marker of SCLC in LEMS
  • SOX1 can be also used in cancer surveillance of LEMS

Other cancers

Drugs

References

  1. Titulaer MJ, Lang B, Verschuuren JJGM. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet 2011; 10:1098-1107.
  2. Weimer MB, Wong J. Lambert-eaton myasthenic syndrome. Curr Treat Options Neurol 2009; 11:77-84.
  3. Sabater L, Titulaer M, Saiz A, Verschuuren J, Gure AO, Graus F. SOX1 antibodies are makers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 2008; 70:924-928.
  4. Gilhus NE. Lambert-eaton myasthenic syndrome; pathogenesis, diagnosis, and therapy. Autoimmune Dis 2011; 2011:973808.
  5. Mareska M, Gutmann L. Lambert-Eaton syndrome. Semin Neurol 2004; 24:149-153.
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