Lambert Eaton myasthenic syndrome (LEMS): cancer management

Evidence-based neurology checklist on lambert eaton myasthenic syndrome (lems): cancer management: Investigations for cancer Computed tomography (CT) scan chest Positron emission tomography (PET) scan: if CT is negative Also see Neurochecklist: “Paraneoplastic neurological syndromes: cancer…

Investigations for cancer

  • Computed tomography (CT) scan chest
  • Positron emission tomography (PET) scan: if CT is negative
  • Also see Neurochecklist: “Paraneoplastic neurological syndromes: cancer screening”

Paraneoplastic risk assessment

DELTA-P scoring items

DELTA-P based cancer screening strategy items

References

  1. Titulaer MJ, Lang B, Verschuuren JJGM. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet 2011; 10:1098-1107.
  2. Sabater L, Titulaer M, Saiz A, Verschuuren J, Gure AO, Graus F. SOX1 antibodies are makers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 2008; 70:924-928.
  3. Titulaer MJ, Maddison P, Sont JK, et al. Clinical Dutch-English Lambert-Eaton mutagenic syndrome (LEMS) tumour association score accurately predicts small-cell lung cancer in the LEMS. J Clin Oncol 2011; 29:902-908.
  4. Weimer MB, Wong J. Lambert-eaton myasthenic syndrome. Curr Treat Options Neurol 2009; 11:77-84.
  5. Kesner VG, Oh SJ, Dimachkie MM, Barohn RJ. Lambert-Eaton myasthenic syndrome. Neurol Clin 2018; 36:379-394.

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