Kleine-Levin syndrome (KLS): clinical features
Evidence-based neurology checklist on kleine-levin syndrome (kls): clinical features: Demographic features This is a syndrome of episodic hypersomnia and compulsive eating It usually affects adolescent men: they account for 70% of cases The peak onset age is 14 years: the range is 11-21 years…
Demographic features
- This is a syndrome of episodic hypersomnia and compulsive eating
- It usually affects adolescent men: they account for 70% of cases
- The peak onset age is 14 years: the range is 11-21 years
Genetics
Precipitating causes
Core features
Features of hypersomnia
Eating disorders
Behavioural features
Compulsions
Neuropsychiatric features
Cognitive features
Other features
Differential diagnosis
Synonym
References
- Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain 2005; 128:2763-2776.
- Dauvilliers Y, Mayer G, Lecendreux M, et al. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analysis. Neurology 2002; 59:1739-1745.
- Al Shareef SM, Basit S, Li S, Pfister C, et al. Kleine-Levin syndrome is associated with LMOD3 variants. J Sleep Res 2018; e12718 (Epub ahead of print).
- Ambati A, Hillary R, Leu-Semenescu S, et al. Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. Proc Natl Acad Sci U S A 2021; 118:e2005753118.
- Groos E, Chaumereuil C, Flamand M, et al. Emerging psychiatric disorders in Kleine-Levin syndrome. J Sleep Res 2018:e12690.
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