Intravenous immunoglobulins (IVIg): complications

Evidence-based neurology checklist on intravenous immunoglobulins (ivig): complications: Thromboembolic stroke Onset Manifestations Management Headache Aseptic meningitis Flu-like symptoms Gastrointestinal complications Cardiovascular complications Dermatological complications Vasomotor…

Thromboembolic stroke

  • Onset
  • Manifestations
  • Management

Headache

Aseptic meningitis

Flu-like symptoms

Gastrointestinal complications

Cardiovascular complications

Dermatological complications

Vasomotor complications

Other systemic complications

Laboratory complications

References

  1. Jiang M, Kimber JS, Gupta A, et al. Adverse reactions associated with intravenous immunoglobulin administration in the treatment of neurological disorders: a systematic review. Int Arch Allergy Immunol 2023; 184:513-528. 
  2. Patwa HS, Chaudhry V, Katzberg H, et al. Evidence-based guideline: intravenous immunoglobulin in the treatment of neuromuscular disorders. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2012; 78:1009-1015.
  3. Association of British Neurologists. Guidelines for the use of intravenous immunoglobulin in neurological diseases. Revised 2005.
  4. Kapoor M, Spillane J, Englezou C, et al. Thromboembolic risk with IVIg: incidence and risk factors in patients with inflammatory neuropathy. Neurology 2020; 94:e635-e638.
  5. Rogers T, White LM, Cooper S, Smith H, Gosal D, Keh RYS. Thromboembolic risk of intravenous and subcutaneous immunoglobulin treatment for neuroinflammatory diseases. JNNP 2026; 97:204-208.
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