Interferons

Evidence-based neurology checklist on interferons: Mode of action Interferons inhibit the migration of B cells into the central nervous system They induce interleukin 10 and 14 (IL-10 and IL-4) They also inhibit pro-inflammatory cytokines e.g. IL-17 Dosing Pegylated interferon (PEG interferon) β1a…

Mode of action

  • Interferons inhibit the migration of B cells into the central nervous system
  • They induce interleukin 10 and 14 (IL-10 and IL-4)
  • They also inhibit pro-inflammatory cytokines e.g. IL-17

Dosing

Pegylated interferon (PEG interferon) β1a

Precaution

Drug-related side effects

Systemic side effects

Neurological side effects

PEG interferon side effects

Monitoring of interferon treatment: indices

Monitoring of interferon treatment: frequency

Precautions

Treatment of injection-site reactions

Acronyms

References

  1. Torkildsen Ø, Myhr KM, Bø L. Disease-modifying treatments for multiple sclerosis – a review of approved medications. Eur J Neurol 2016; 23(Suppl 1):18-27.
  2. Rejdak K, Jackson S, Giovannoni G. Multiple sclerosis: a practical overview for clinicians. Br Med Bull 2010; 95:79-104.
  3. Rice CM. Disease modification in multiple sclerosis: an update. Pract Neurol 2014; 14:6-13.
  4. Dargahi N, Katsara M, Tselios T, et al. Multiple sclerosis: immunopathology and treatment update. Brain Sci 2017; 7(7) pii: E78. 
  5. Wingerchuk DM, Weinshenker BG. Disease modifying therapies for relapsing multiple sclerosis. BMJ 2016; 354:i3518.
  6. And 11 more. Subscribe to see the full list

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