Inflammatory bowel disease (IBD): neurological features

Evidence-based neurology checklist on inflammatory bowel disease (ibd): neurological features: Pathophysiological mechanisms Immune mediated damage Brain-gut axis dysfunction Thromboembolism: arterial and venous Infections Nutritional deficiencies Anti-TNF-α side effects: Other medication side…

Pathophysiological mechanisms

  • Immune mediated damage
  • Brain-gut axis dysfunction
  • Thromboembolism: arterial and venous
  • Infections
  • Nutritional deficiencies
  • Anti-TNF-α side effects:
  • Other medication side effects

CNS demyelination

Vascular features

Other central neurological features

Peripheral nerve features

Muscle features

Psychiatric features

Acronym

References

  1. Ferro JM, Oliveira Santos M. Neurology of inflammatory bowel disease. J Neurol Sci 2021; 424:117426. 
  2. Morís G. Inflammatory bowel disease: an increased risk factor for neurologic complications. World J Gastroenterol 2014; 20:1228-1237. 
  3. De Felice KM, Novotna M, Enders FT, et al. Idiopathic inflammatory demyelinating disease of the central nervous system in patients with inflammatory bowel disease: retrospective analysis of 9095 patients. Aliment Pharmacol Ther 2015; 41:99-107.
  4. Cortese R, Prosperini L, Stasolla A, et al. Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy. J Neurol 2021; 268:2895-2899. 
  5. Kunchok A, Aksamit AJ Jr, Davis JM 3rd, et al. Association between tumor necrosis factor inhibitor exposure and inflammatory central nervous system events. JAMA Neurol 2020; 77:937-946.
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