Immune checkpoint inhibitor (ICI) paraneoplastic syndrome (PNS): clinical features

Evidence-based neurology checklist on immune checkpoint inhibitor (ici) paraneoplastic syndrome (pns): clinical features: Frequent primary cancers Lung Melanoma Merkel cell carcinoma Other primary cancers Paraneoplastic syndromes Clinical features Outcome

Frequent primary cancers

  • Lung
  • Melanoma
  • Merkel cell carcinoma

Other primary cancers

Paraneoplastic syndromes

Clinical features

Outcome

References

  1. Zhang L, Fan S, Wang J, Ren H, Guan H. Antibody-positive paraneoplastic neurological syndromes associated with immune checkpoint inhibitors: a systematic review. J Neurol 2025; 272:249. 
  2. Farina A, Villagrán-García M, Vogrig A, et al. Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes. Lancet Neurol 2024; 23:81-94.
  3. Shi GQ, Lian HN, Wang H, Xia JQ, Ma LJ, Zhou J. Case report: Immune checkpoint inhibitor-induced paraneoplastic neurological syndrome in two patients: a case series. Front Oncol 2024; 14:1404829.
  4. Vilaseca A, Farina A, Villagrán-García M, et al. Neurological autoimmunity in melanoma patients: a comparison between those exposed and non-exposed to immune checkpoint inhibitors. J Neurol 2024; 271:3279-3290.
  5. Valencia-Sanchez C, Zekeridou A. Paraneoplastic neurological syndromes and beyond emerging with the introduction of immune checkpoint inhibitor cancer immunotherapy. Front Neurol 2021; 12:642800.
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