Hyperkalaemic periodic paralysis: management

Evidence-based neurology checklist on hyperkalaemic periodic paralysis: management: Electromyogram (EMG): McManis test The test is done during 2-5 minutes of intermittent muscle contractions There is an abnormal increase in the compound muscle action potential (CMAP) This is followed by…

Electromyogram (EMG): McManis test

  • The test is done during 2-5 minutes of intermittent muscle contractions
  • There is an abnormal increase in the compound muscle action potential (CMAP)
  • This is followed by progressive abnormal reduction in the CMAP
  • The reduction is most marked in the first 20 minutes post-exertion
  • The test is also positive in other periodic paralyses

Preventative activities

Things to avoid

Treatment

Anaesthetic management

General management

References

  1. Venance SL, Cannon SC, Fialho D, et al. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain 2006; 129:8-17. 
  2. Finsterer J. Primary periodic paralyses. Acta Neurol Scand 2008; 117:145-158.
  3. McManis PG, Lambert EH, Daube JR. The exercise test in periodic paralysis. Muscle Nerve 1986; 9:704-710.
  4. Statland JM, Fontaine B, Hanna MG, et al. Review of the diagnosis and treatment of periodic paralysis. Muscle Nerve 2018; 57:522-530.
  5. Atoot A, Paganessi M, Block M, Schlesinger MD. Anesthetic management in familial hyperkalemic periodic paralysis: a case report. Cureus 2021; 13:e19889. 
  6. And 1 more. Subscribe to see the full list

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