Huntington’s disease (HD): pre-manifest features
Evidence-based neurology checklist on huntington’s disease (hd): pre-manifest features: Pre-manifest motor features Subtle chorea Subtle gait disorder Impaired rapid alternating movements Impaired precision grip Impaired saccades Impaired motor planning and speed Pre-manifest non-motor features
Pre-manifest motor features
- Subtle chorea
- Subtle gait disorder
- Impaired rapid alternating movements
- Impaired precision grip
- Impaired saccades
- Impaired motor planning and speed
Pre-manifest non-motor features
References
- Kirkwood SC, Siemers E, Hodes ME, Conneally PM, Christian JC, Foroud T. Subtle changes among presymptomatic carriers of the Huntington's disease gene. JNNP 2000; 69:773-779.
- Tabrizi SJ, Scahill RI, Durr A, et al. Biological and clinical changes in premanifest and early stage Huntington’s disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol 2011; 10:31-42.
- Rao AK, Gordon AM, Marder KS. Coordination of fingertip forces during precision grip in premanifest Huntington's disease. Mov Disord 2011; 26:862-869.
- Blekher T, Johnson SA, Marshall J, et al. Saccades in presymptomatic and early stages of Huntington disease. Neurology 2006; 67:394-399.
- Harrington DL, Smith MM, Zhang Y, et al. Cognitive domains that predict time to diagnosis in prodromal Huntington disease. JNNP 2012; 83:612-619.
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