HaNDL

Evidence-based neurology checklist on handl: Risk factors Human herpes virus 6 (HHV6) Human herpes virus 7 (HHV7) Epstein-Barr virus (EBV) COVID-19 Borrelia lusitaniae P/Q and T type voltage gated calcium channel antibodies Clinical features Associated ophthalmic features Other associated features…

Risk factors

  • Human herpes virus 6 (HHV6)
  • Human herpes virus 7 (HHV7)
  • Epstein-Barr virus (EBV)
  • COVID-19
  • Borrelia lusitaniae
  • P/Q and T type voltage gated calcium channel antibodies

Clinical features

Associated ophthalmic features

Other associated features

Differential diagnosis: infections

Differential diagnosis: others

Cerebrospinal fluid (CSF) analysis

Electroencephalogram (EEG)

Magnetic resonance imaging (MRI) brain

Treatment options: case reports

Acronym

References

  1. Emond H, Schnorf H, Poloni C, Vulliemoz S, Lalive PH. Syndrome of transient headache and neurological deficits with CSF lymphocytosis (HaNDL) associated with recent human herpesvirus-6 infection. Cephalalgia 2009; 29:487-491.
  2. Gomez-Aranda F, Canadillas F, Marti-Masso JF, et al. Pseudomigraine with temporary neurological symptoms and lymphocytic pleocytosis. A report of 50 cases. Brain 1997; 120:1105-1113.
  3. Segura T, Hernandez-Fernandez F, Sanchez-Ayaso P, Lozano E, Abad L. Usefulness of multimodal MR imaging in the differential diagnosis of HaNDL and acute ischemic stroke. BMC Neurol 2010; 10:120. 
  4. Cifelli A, Vaithianathar L. Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL). BMJ Case Reports 2011; 10.1136/bcr.03.2010.2862.
  5. Sundholm A, Gustafsson R, Karrenbauer V. Syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL): HHV-7 finding in cerebrospinal fluid challenges diagnostic criteria. Pathogens 2023; 12:476.
  6. And 23 more. Subscribe to see the full list

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