Giant tumefactive perivascular spaces (GTPVS)

Evidence-based neurology checklist on giant tumefactive perivascular spaces (gtpvs): Pathology These are perivascular spaces that are >1.5cm They are unilocular or multilocular They are most frequently located in the midbrain and thalamus They are low attenuation on computerized tomography (CT)…

Pathology

  • These are perivascular spaces that are >1.5cm
  • They are unilocular or multilocular
  • They are most frequently located in the midbrain and thalamus
  • They are low attenuation on computerized tomography (CT)
  • They are isointense on magnetic resonance imaging (MRI)
  • They have the same signal intensity as cerebrospinal fluid (CSF)
  • They do not enhance with contrast
  • There is no associated calcification
  • They tend to remain stable on long-term follow up
  • They may spontaneously regress

Potential pathophysiological mechanisms

Clinical features

Complications

Differential diagnosis

Treatment

Synonyms

Acronyms

References

  1. Salzman KL, Osborn AG, House P, et al. Giant tumefactive perivascular spaces. Am J Neuroradiol 2005; 26:298-305.
  2. Hao X, Zhu M, Tan L, Huang Y, Zhang J. Giant tumefactive perivascular spaces. Radiol Case Rep 2023; 18:3196-3198.
  3. Sankararaman S, Velayuthan S, Ambekar S, Gonzalez-Toledo E. Giant tumefactive perivascular spaces: a further case. J Pediatr Neurosci 2013; 8:108-110.
  4. Mizutani H, Misumi Y, Ueda M. Teaching NeuroImage: Giant tumefactive perivascular spaces: longitudinal follow-up. Neurology 2024; 103:e209643.
  5. Cerase A, Vallone IM, Muccio CF, Petrini C, Signori G, Venturi C. Regression of dilated perivascular spaces of the brain. Surg Radiol Anat 2010; 32:555-561.
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