Germ cell tumours: tumour markers and genetics

Evidence-based neurology checklist on germ cell tumours: tumour markers and genetics: Alpha-fetoprotein (AFP) Endodermal sinus tumours Mixed germ cell tumours Immature teratomas Beta human chorionic gonadotrophi (beta hCG) Placental alkaline phosphatase (PLAP) C-KIT Genetic mutations

Alpha-fetoprotein (AFP)

  • Endodermal sinus tumours
  • Mixed germ cell tumours
  • Immature teratomas

Beta human chorionic gonadotrophi (beta hCG)

Placental alkaline phosphatase (PLAP)

C-KIT

Genetic mutations

References

  1. Echevarría ME, Fangusaro J, Goldman S. Pediatric central nervous system germ cell tumors: a review. Oncologist 2008; 13:690-699.
  2. Aihara Y, Watanabe S, Amano K, et al. Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. J Neurosurg 2018; doi: 10.3171/2018.3.JNS172520 (Epub ahead of print).
  3. Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y. Central nervous system germ cell tumors: a review of the literature. J Child Neurol 2018; 33:610-620.
  4. Dufour C, Guerrini-Rousseau L, Grill J. Central nervous system germ cell tumors: an update. Curr Opin Oncol 2014; 26:622-626.

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