Facial onset sensory and motor neuronopathy (FOSMN): clinical features

Evidence-based neurology checklist on facial onset sensory and motor neuronopathy (fosmn): clinical features: Demographic features This usually occurs in males The mean onset age is 43 years Major features Other features Course Differential diagnosis Acronym

Demographic features

  • This usually occurs in males
  • The mean onset age is 43 years

Major features

Other features

Course

Differential diagnosis

Acronym

References

  1. Vucic S, Tian D, Chong ST, Cudkowicz ME, Hedley-Whyte ET, Cros D. Facial onset sensory and motor neuronopathy (FOSMN syndrome): a novel syndrome in neurology. Brain 2006; 129:3384-3390.
  2. Vucic S, Stein TD, Hedley-Whyte ET, et al. FOSMN syndrome: novel insight into disease pathophysiology. Neurology 2012; 79:73-79.
  3. Ziso B, Williams T, Walters J, Jaiser S, Wieshmann U, Jacob A. FOSMN: Facial onset sensory motor neuronopathy. A 'benign' differential diagnosis to bulbar onset motor neuron disease. The first cohort from the UK. JNNP 2013; 84:e2.
  4. Sonoda K, Sasaki K, Tateishi T, et al. TAR DNA-binding protein 43 pathology in a case clinically diagnosed with facial-onset sensory and motor neuronopathy syndrome: an autopsied case report and a review of the literature. J Neurol Sci 2013; 332:148-153.
  5. Hu N, Zhang L, Yang X, Fu H, Cui L, Liu M. Facial onset sensory and motor neuronopathy (FOSMN syndrome): cases series and systematic review. Neurol Sci 2023; 44:1969-1978.
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