Essential tremor (ET): non-drug treatment
Evidence-based neurology checklist on essential tremor (et): non-drug treatment: Deep brain stimulation (DBS) This has Level C evidence: it is possibly effective The target is the ventral intermediate nucleus of the thalamus It may be complicated by progressive gait ataxia The efficacy diminishes…
Deep brain stimulation (DBS)
- This has Level C evidence: it is possibly effective
- The target is the ventral intermediate nucleus of the thalamus
- It may be complicated by progressive gait ataxia
- The efficacy diminishes with time
Gamma knife thalamotomy (stereotactic radiosurgery)
MRI-guided focused ultrasound (MRgFUS) thalamotomy
Other treatments
Investigational treatments
References
- Zesiewicz TA, Elble RJ, Louis ED, et al. Evidence-based guideline update: treatment of essential tremor. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2011; 77:1752-1755.
- Deuschl G, Raethjen J, Hellriegel H, Elbe R. Treatment of patients with essential tremor. Lancet Neurol 2011; 10:148-161.
- Zhang K, Bhatia S, Oh MY, Cohen D, Angle C, Whiting D. Long-term results of thalamic deep brain stimulation for essential tremor. J Neurosurg 2010; 112:1271-1276.
- Reich MM, Brumberg J, Pozzi NG, et al. Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy? Brain 2016; pii: aww223 (Epub ahead of print).
- Paschen S, Forstenpointner J, Becktepe J, et al. Long-term efficacy of deep brain stimulation for essential tremor: an observer-blinded study. Neurology 2019; 92:e1378-e1386.
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