Epilepsy vagus nerve stimulation (VNS)

Evidence-based neurology checklist on epilepsy vagus nerve stimulation (vns): Indications Refractory partial onset seizures in adults >12 years who are not suitable for surgery Partial or generalised seizures in children Lennox-Gastaut syndrome (LGS) Mood improvement in adult epilepsy Outcome…

Indications

  • Refractory partial onset seizures in adults >12 years who are not suitable for surgery
  • Partial or generalised seizures in children
  • Lennox-Gastaut syndrome (LGS)
  • Mood improvement in adult epilepsy

Outcome

Predictors of poor response

Side effects

References

  1. Fisher RS, Handforth A. Reassessment: vagus nerve stimulation for epilepsy: a report of the Therapeutics and Technology Assessment Subcomittee of the American Academy of Neurology. Neurology 1999; 53:666-669.
  2. Morris GL 3rd, Gloss D, Buchhalter J, Mack KJ, Nickels K, Harden C. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2013; 81:1453-1459.
  3. Moshref R, Burneo JG, Steven DA, et al. Vagus nerve stimulation in lesional and Non-Lesional Drug-Resistant focal onset epilepsies. Epilepsy Behav 2024; 159:109948. 
  4. Brodtkorb E, Samsonsen C, Jørgensen JV, Helde G. Epilepsy patients with and without perceived benefit from vagus nerve stimulation: a long-term observational single center study. Seizure 2019; 72:28-32.
  5. Janszky J, Hoppe M, Behne F, Tuxhorn I, Pannek HW, Ebner A. Vagus nerve stimulation: predictors of seizure freedom. JNNP 2005; 76:384-389.
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