Epilepsia partialis continua (EPC): management

Evidence-based neurology checklist on epilepsia partialis continua (epc): management: Electroencephalogram (EEG) There are irregular focal cortical discharges These are usually discrete spikes, sharp waves or slow wave activity There may be periodic lateralised epileptiform discharges (PLEDs) The…

Electroencephalogram (EEG)

  • There are irregular focal cortical discharges
  • These are usually discrete spikes, sharp waves or slow wave activity
  • There may be periodic lateralised epileptiform discharges (PLEDs)
  • The features persist in sleep: the background here may be generalised

Other investigations

Main treatments

Anecdotal treatments

References

  1. Mameniškienė R, Wolf P. Epilepsia partialis continua: a review. Seizure 2017; 44:74-80. 
  2. Cockerell OC, Rothwell J, Thompson PD, Marsden CD, Shorvon SD. Clinical and physiological features of epilepsia partialis continua. Cases ascertained in the UK. Brain 1996; 119:393-407. 
  3. Surana S, Rossor T, Hassell J, et al. Diagnostic algorithm for children presenting with epilepsia partialis continua. Epilepsia 2020; 61:2224-2233.
  4. De Benedictis A, Freri E, Rizzi M, et al. Vagus nerve stimulation for drug-resistant epilepsia partialis continua: report of four cases. Epilepsy Res 2013; 107:163-171.
  5. Chang D, Singhal NS, Tarapore PE, Auguste KI. Repetitive transcranial magnetic stimulation (rTMS) as therapy in an infant with epilepsia partialis continua Epilepsy Behav Rep 2021; 18:100511.
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