Encephalitis lethargica

Evidence-based neurology checklist on encephalitis lethargica: Background This is possibly an autoimmune disorder Its relationship to the great influenza epidemic is not established It may have an enteroviral etiology Pathology Common types of encephalitis lethargica Clinical features…

Background

  • This is possibly an autoimmune disorder
  • Its relationship to the great influenza epidemic is not established
  • It may have an enteroviral etiology

Pathology

Common types of encephalitis lethargica

Clinical features

Cerebrospinal fluid (CSF) analysis

Magnetic resonance imaging (MRI)

Autoantibodies

Treatment

References

  1. Dale RC, Church AJ, Surtees RA, et al. Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain 2004; 127:21-23.
  2. McCall S, Vilensky JA, Gilman S, Taubenberger JK. The relationship between encephalitis lethargica and influenza: a critical analysis. J Neurovirol 2008; 14:177-185.
  3. Dourmashkin RR, Dunn G, Castano V, McCall SA. Evidence for an enterovirus as the cause of encephalitis lethargica. BMC Infect Dis 2012; 12:136.
  4. Vilensky JA. Gilman S. Encephalitis lethargica: could this disease be recognised if the epidemic recurred? Pract Neurol 2006; 6:360-367.
  5. Ward CD. On doing nothing: descriptions of sleep, fatigue, and motivation in encephalitis lethargica. Mov Disord 2011; 26:599-604.

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