Ebola virus disease (EVD): management

Evidence-based neurology checklist on ebola virus disease (evd): management: Virological investigations Reverse transcriptase polymerase chain reaction (RT-PCR): this detects Ebola RNA Enzyme-linked immunosorbent assay (ELISA): this detects viral antigens Viral load: in blood, urine, and…

Virological investigations

  • Reverse transcriptase polymerase chain reaction (RT-PCR): this detects Ebola RNA
  • Enzyme-linked immunosorbent assay (ELISA): this detects viral antigens
  • Viral load: in blood, urine, and cerebrospinal fluid (CSF)
  • Next generation sequencing (NGC): for screening

Blood investigations

Preventative measures

Supportive treatment

Immunotherapy

Drugs with potential to treat/limit transmission

Investigational treatments

References

  1. Billioux BJ, Smith B, Nath A. Neurological complications of Ebola virus infection. Neurotherapeutics 2016; 13:461-470. 
  2. Martínez MJ, Salim AM, Hurtado JC, Kilgore PE. Ebola virus infection: overview and update on prevention and treatment. Infect Dis Ther 2015; 4:365-390.  
  3. Uyeki TM, Mehta AK, Davey RT Jr, et al; Working Group of the U.S.–European Clinical Network on Clinical Management of Ebola Virus Disease Patients in the U.S. and Europe. Clinical management of Ebola Virus Disease in the United States and Europe. N Engl J Med 2016; 374:636-646. 
  4. Koenig KL, Majestic C, Burns MJ. Ebola virus disease: essential public health principles for clinicians. West J Emerg Med 2014; 15:728-731.
  5. Wolf T, Kann G, Becker S, et al. Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care. Lancet 2015; 385:1428-1435. 
  6. And 3 more. Subscribe to see the full list

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