DYT21: Late onset dystonia

Evidence-based neurology checklist on dyt21: late onset dystonia: Genetics This is caused by mutations in chromosome 2 The transmission is autosomal dominant It causes late onset dystonia The onset age is 13-50 years: it is usually around 25 years Dystonia phenotypes Treatment

Genetics

  • This is caused by mutations in chromosome 2
  • The transmission is autosomal dominant
  • It causes late onset dystonia
  • The onset age is 13-50 years: it is usually around 25 years

Dystonia phenotypes

Treatment

References

  1. Norgren N, Mattson E, Forsgren L, Holmberg M. A high-penetrance form of late-onset torsion dystonia maps to a novel locus (DYT21) on chromosome 2q14.3-q21.3. Neurogenetics 2011; 12:137-143. 
  2. Forsgren L, Holmgren G, Almay BG, Drugge U. Autosomal dominant torsion dystonia in a Swedish family. Adv Neurol 1988; 50:83-92.

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