Duane retraction syndrome (DRS): clinical features

Evidence-based neurology checklist on duane retraction syndrome (drs): clinical features: Causes This is caused by mutations in the DURS2 gene on chromosome 2 in 10% of families It may be sporadic Clinical features

Causes

  • This is caused by mutations in the DURS2 gene on chromosome 2 in 10% of families
  • It may be sporadic

Clinical features

References

  1. Demer JL, Clark RA, Lim KH, Engle EC. Magnetic resonance imaging evidence for widespread orbital dysinnervation in dominant Duane's retraction syndrome linked to the DURS2 locus. Invest Ophthalmol Vis Sci 2007; 48:194-202.
  2. Yonghong J, Kanxing Z, Zhenchang W, et al. Detailed magnetic resonance imaging findings of the ocular motor nerves in Duane's retraction syndrome. J Pediatr Ophthalmol Strabismus 2009; 46:278-285. 
  3. Xia S, Li RL, Li YP, Qian XH, Chong V, Qi J. MRI findings in Duane's ocular retraction syndrome. Clin Radiol 2014; 69:e191-e198.
  4. Miyake N, Chilton J, Psatha M, et al. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science 2008; 321:839-843.

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