Down’s syndrome: neurological features
Evidence-based neurology checklist on down’s syndrome: neurological features: Alzheimer’s disease This develops in >90% of cases It sets in at about the age of 40 years It is associated with gait dyspraxia Other cognitive features Late onset myoclonic epilepsy in Down’s syndrome (LOMEDS) Other…
Alzheimer’s disease
- This develops in >90% of cases
- It sets in at about the age of 40 years
- It is associated with gait dyspraxia
Other cognitive features
Late onset myoclonic epilepsy in Down’s syndrome (LOMEDS)
Other seizure features
Vascular features
Psychiatric features
Gait impairment
Other features
References
- Santoro JD, Pagarkar D, Chu DT, et al. Neurologic complications of Down syndrome: a systematic review. J Neurol 2021; 268:4495-4509.
- Lott IT. Neurological phenotypes for Down syndrome across the life span. Prog Brain Res 2012; 197:101-121.
- Noble J. Natural history of Down's syndrome: a brief review for those involved in antenatal screening. J Med Screen 1998; 5:172-177.
- Lott IT, Dierssen M. Cognitive deficits and associated neurological complications in individuals with Down's syndrome. Lancet Neurol 2010; 9:623-633.
- Ballard C, Mobley W, Hardy J, Williams G, Corbett A. Dementia in Down's syndrome. Lancet Neurol 2016; 15:622-636.
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