Downbeat nystagmus
Evidence-based neurology checklist on downbeat nystagmus: Clinical features This is nystagmus typified by slow upward drifts and fast downwards phases It is poorly suppressed by visual fixation It may be evoked by looking down and outwards It shows a variable response to convergence It may be…
Clinical features
- This is nystagmus typified by slow upward drifts and fast downwards phases
- It is poorly suppressed by visual fixation
- It may be evoked by looking down and outwards
- It shows a variable response to convergence
- It may be worsened by the head hanging position
Idiopathic types
Neurodegenerative causes
Autoimmune causes
Drug-induced
Other causes
Functional magnetic resonance imaging (MRI)
Treatment
References
- Wagner JN, Glaser M, Brandt T, Strupp M. Downbeat nystagmus: aetiology and comorbidity in 117 patients. JNNP 2008; 79:672-677.
- Serra A, Leigh RJ. Diagnostic value of nystagmus: spontaneous and induced ocular oscillations. JNNP 2002; 73:615–618.
- Hüfner K, Stephan T, Kalla R, et al. Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus. Neurology 2007; 69:1128-1135.
- Helmchen C, Machner B, von der Gablentz J, Sprenger A, Zee DS. Downbeat nystagmus is abolished by alcohol in nonalcoholic wernicke encephalopathy. Neurol Clin Pract 2022; 12:e129-e132.
- Serra A, Chisari CG, Matta M. Eye movement abnormalities in multiple sclerosis: pathogenesis, modeling, and treatment. Front Neurol 2018; 9:31.
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