Diaphragmatic paralysis: systemic causes

Evidence-based neurology checklist on diaphragmatic paralysis: systemic causes: Medical causes Idiopathic: this may respond to Valaciclovir Phrenic nerve trauma: from cardiac or neck surgery Hypothyroidism Malignant invasion Trauma Amyloidosis Giant cell arteritis IgG kappa monoclonal gammopathy…

Medical causes

  • Idiopathic: this may respond to Valaciclovir
  • Phrenic nerve trauma: from cardiac or neck surgery
  • Hypothyroidism
  • Malignant invasion
  • Trauma
  • Amyloidosis
  • Giant cell arteritis
  • IgG kappa monoclonal gammopathy
  • Lung hyperinflation
  • Prolonged vomiting

Infective causes

Autoimmune causes

Drug-induced and toxic causes

References

  1. McCool FD, Tzelepis GE. Dysfunction of the diaphragm. N Engl J Med 2012; 366:932-942.
  2. Gibson GJ. Diaphragmatic paresis: pathophysiology, clinical features, and investigation. Thorax 1989; 44:960-970.
  3. Bell D, Siriwardena A. Phrenic nerve injury following blunt trauma. J Accid Emerg Med 2000; 17:419-420.
  4. Burton EA, Winer JB, Barber PC. Giant cell arteritis of the cervical radicular vessels presenting with diaphragmatic weakness. JNNP 1999; 67:223-226.
  5. Dozier CE, Sztajzel R, Kohler A, Chofflon M, Magistris MR, Floch JR-L. Diaphragmatic paralysis with monoclonal gammopathy and antiganglioside GM1 antibodies. Neurology 1999; 52:1715-1716.
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