Dermatomyositis associated antibodies
Evidence-based neurology checklist on dermatomyositis associated antibodies: MDA5 This causes amyopathic or pauci-myopathic dermatomyositis It presents with rapidly progressive severe interstitial lung disease It also presents with classical or atypical dermatomyositis rash Mechanic’s hands and…
MDA5
- This causes amyopathic or pauci-myopathic dermatomyositis
- It presents with rapidly progressive severe interstitial lung disease
- It also presents with classical or atypical dermatomyositis rash
- Mechanic’s hands and palmar papules (inverse Gottron) are characteristic
- It may manifest with oral pain and ulcers
- It also presents with hair loss, digital ulcers, panniculitis, and polyarthritis
TIF-γ
TIF-1α
SAE
NXP2 (anti MJ2)
Mi-2 (α and β)
Acronyms
References
- Rietveld A, Lim J, de Visser M, et al. Autoantibody testing in idiopathic inflammatory myopathies. Pract Neurol 2019; 19:284-294.
- Stuhlmüller B, Schneider U, González-González JB, Feist E. Disease specific autoantibodies in idiopathic inflammatory myopathies. Front Neurol 2019; 10:438.
- Hall JC, Casciola-Rosen L, Samedy LA, et al. Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum. Arthritis Care Res (Hoboken) 2013; 65:1307-1315.
- Labrador-Horrillo M, Martinez MA, Selva-O'Callaghan A, et al. Anti-MDA5 antibodies in a large Mediterranean population of adults with dermatomyositis. J Immunol Re. 2014; 2014:290797.
- Muro Y, Sugiura K, Akiyama M. Cutaneous manifestations in dermatomyositis: key clinical and serological features-a comprehensive review. Clin Rev Allergy Immunol.2016; 51:293-302.
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