Delayed post-hypoxic leukoencephalopathy (DPHL)

Evidence-based neurology checklist on delayed post-hypoxic leukoencephalopathy (dphl): Pathogenesis This is a demyelinating syndrome It follows a period of prolonged cerebral hypoxia Causes Predisposing factors Clinical features Magnetic resonance imaging (MRI) brain: features Pathology: features

Pathogenesis

  • This is a demyelinating syndrome
  • It follows a period of prolonged cerebral hypoxia

Causes

Predisposing factors

Clinical features

Magnetic resonance imaging (MRI) brain: features

Pathology: features

References

  1. Shprecher D, Mehta L. The syndrome of delayed post-hypoxic leukoencephalopathy. NeuroRehabilitation 2010; 26:65-72.
  2. Nzwalo H, Sá F, Cordeiro I, Ferreira F, Basílio C. Delayed hypoxic-ischemic leukoencephalopathy. BMJ Case Rep 2011; pii: bcr0620114344.
  3. Katyal N, Narula N, George P, Nattanamai P, Newey CR, Beary JM. Delayed post-hypoxic leukoencephalopathy: a case series and review of the literature. Cureus 2018; 10:e2481.
  4. Molloy S, Soh C, Williams TL. Reversible delayed posthypoxic leukoencephalopathy. Am J Neuroradiol 2006; 27:1763-1765.
  5. Aljarallah S, Al-Hussain F. Acute fatal posthypoxic leukoencephalopathy following benzodiazepine overdose: a case report and review of the literature. BMC Neurol 2015; 15:69.
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