Creutzfeldt Jakob disease (CJD): investigations

Magnetic resonance imaging (MRI): high signal changes

• These are in the caudate, putamen or cortical regions
• These are mainly near the midline
• They have also been reported in the globus pallidus

Magnetic resonance imaging (MRI): cortical ribbon sign

Magnetic resonance imaging (MRI): other changes

Magnetic resonance spectroscopy (MRS)

Cerebrospinal fluid (CSF): routine indices

Cerebrospinal fluid (CSF): specific indices

Electroencephalogram (EEG)

Skin biopsy

Synonym

References

1. Mahillo-Fernandez I, de Pedro-Cuesta J, Bleda MJ, et al. Surgery and risk of sporadic Creutzfeldt-Jakob disease in Denmark and Sweden: registry-based case-control study. Neuroepidemiology 2008; 31:229-240.
2. Tschampa HJ, Kallenberg K, Kretzschmar HA, et al. Pattern of cortical changes in sporadic Creutzfeldt-Jakob disease. AJNR 2007; 28:1114-1118.
3. de Priester JA, Jansen GH, de Kruijk JR, Wilmink JT. New MRI findings in Creutzfeldt-Jakob disease: high signal in the globus pallidus on T1-weighted images. Neuroradiology 1999; 41:265-268.
4. Chen Z, Kong Y, Wu L. Punctate diffuse cortex signals in Creutzfeldt-Jakob disease. JAMA Neurol 2024; 81:291-292.
5. Yasuda M, Sugiyama A, Hokkoku H, et al. Propagation of diffusion-weighted MRI abnormalities in the preclinical stage of sporadic Creutzfeldt-Jakob Disease. Neurology 2022; 99:699-702.
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Related checklists

• Creutzfeldt Jakob disease (CJD): clinical features
• Creutzfeldt Jakob disease (CJD): differential diagnosis
• Creutzfeldt Jakob disease (CJD): treatment
• New variant Creutzfeldt Jakob disease (nvCJD)