Coronavirus SARS-CoV-2 infection: peripheral features

Evidence-based neurology checklist on coronavirus sars-cov-2 infection: peripheral features: Guillain Barre syndrome (GBS) The mean onset age is 55-59 years: the range is 11-94 years The mean onset time is 11 days after COVID Males account for about 65-68% of cases It is demyelinating in about 50%…

Guillain Barre syndrome (GBS)

  • The mean onset age is 55-59 years: the range is 11-94 years
  • The mean onset time is 11 days after COVID
  • Males account for about 65-68% of cases
  • It is demyelinating in about 50% of cases
  • Features are usually typical of classic GBS
  • It may present as the pharyngeal-cervical-brachial variant
  • It may also manifest as acute motor axonal neuropathy (AMAN)
  • Cerebrospinal fluid (CSF) was negative for SARS-CoV-2 RNA in all cases
  • Most cases respond to a single course of intravenous immunoglobulin (IVIg)
  • Causality is uncertain as the incidence is not considered higher than expected
  • There are also many case reports of Miller Fisher syndrome (MFS)

Muscle features

Peripheral nerve features

Others

Synonym

References

  1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395:497-506.
  2. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395:507-513.
  3. Guo YR, Cao QD, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status. Mil Med Res 2020; 7:11.  
  4. Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M. Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases. J Neurol 2020 (Online ahead of print).
  5. Caress JB, Castoro RJ, Simmons Z, Scelsa SN, Lewis RA, Ahlawat A, Narayanaswami P. COVID-19-associated Guillain-Barré syndrome: the early pandemic experience. Muscle Nerve 2020 (Online ahead of print).
  6. And 48 more. Subscribe to see the full list

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