Congenital myasthenic syndrome (CMS): drug treatment

Evidence-based neurology checklist on congenital myasthenic syndrome (cms): drug treatment: Pyridostigmine: indications ChAT Sodium channel Fast channel Rapsyn Pyridostigmine: contraindications 3,4 diaminopyridine (3,4 DAP): indications 3,4 diaminopyridine (3,4 DAP): contraindications Treatment of…

Pyridostigmine: indications

  • ChAT
  • Sodium channel
  • Fast channel
  • Rapsyn

Pyridostigmine: contraindications

3,4 diaminopyridine (3,4 DAP): indications

3,4 diaminopyridine (3,4 DAP): contraindications

Treatment of slow channel

Treatment of DOK7

References

  1. Spillane J, Beeson DJ, Kullmann DM. Myasthenia and related disorders of the neuromuscular junction. JNNP 2010; 81:850-857.
  2. Bertorini TE. Neuromuscular Disorders: Treatment and Management. Elsevier Philadelphia 2011 p334.
  3. Finlayson S, Beeson D, Palace J. Congenital myasthenic syndrome: an update. Pract Neurol 2013; 13:80-91.
  4. Harper CM, Fukodome T, Engel AG. Treatment of slow-channel congenital myasthenic syndrome with fluoxetine. Neurology 2003; 60:1710-1713.
  5. Peyer AK, Abicht A, Heinimann K, Sinnreich M, Fischer D. Quinine sulfate as a therapeutic option in a patient with slow channel congenital myasthenic syndrome. Neuromuscul Disord 2013; 23:571-574. 
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