Chorea: management
Evidence-based neurology checklist on chorea: management: Investigations Full blood count Blood film Serum caeruloplasmin/urine copper Antinuclear antibody (ANA) Anti dsDNA Lupus anticoagulant Anti-cardiolipin antibody Anti-streptolysin O (ASO) titre Anti-basal ganglia antibody (ABGA) Thyroid…
Investigations
- Full blood count
- Blood film
- Serum caeruloplasmin/urine copper
- Antinuclear antibody (ANA)
- Anti dsDNA
- Lupus anticoagulant
- Anti-cardiolipin antibody
- Anti-streptolysin O (ASO) titre
- Anti-basal ganglia antibody (ABGA)
- Thyroid function test (TFT)
- Magnetic resonance imaging (MRI) brain
- Cerebrospinal fluid (CSF) analysis
Good-evidenced drug treatments
Neuroleptics
Vesicular monoamine transporter 2 (VMAT2) blockers
Other drug treatments
References
- Wild EJ, Tabrizi SJ. The differential diagnosis of chorea. Pract Neurol 2007; 7:360-373.
- Armstrong MJ, Miyasaki JM. Evidence-based guideline: pharmacologic treatment of chorea in Huntington's disease: report of the Guideline Development Subcommitteeof the American Academy of Neurology. Neurology 2012; 79:597.
- Novak MJU, Tabrizi SJ. Huntington's disease. BMJ 2010; 340:c3109.
- Jankovic J. Dopamine depleters in the treatment of hyperkinetic movement disorders. Expert Opin Pharmacother 2016; 17:2461-2470.
- Huntington Study Group, Frank S, Testa CM, Stamler D, et al. Effect of deutetrabenazine on chorea among patients with huntington disease: a randomized clinical trial. JAMA 2016; 316:40-50.
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