Cerebrospinal fluid (CSF): protein

Evidence-based neurology checklist on cerebrospinal fluid (csf): protein: Determinants of CSF protein concentration Patient’s age: it is higher in neonates and in those >60 years Site of CSF collection Technique of collection Examining laboratory Causes of mildly raised CSF protein (45-75mg/dL)…

Determinants of CSF protein concentration

  • Patient’s age: it is higher in neonates and in those >60 years
  • Site of CSF collection
  • Technique of collection
  • Examining laboratory

Causes of mildly raised CSF protein (45-75mg/dL)

Causes of moderately raised CSF protein (75-500mg/dL)

Causes of severely raised CSF protein (>500mg/dL)

Causes of low CSF protein

CSF biomarkers of bacterial meningitis with traumatic LP

References

  1. Bhidayasiri R, Waters MF, Giza CC. Neurological differential diagnosis. A prioritized approach. Blackwell publishing Massachussetts 2005 p491-492.
  2. Diesenhammer F, Bartos A, Egg R, et al. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. Eur J Neurol 2006; 13:913-922.
  3. Seehusen DA, Reeves MM, Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician 2003; 68:1103-1108.
  4. Nazir M, Wani WA, Kawoosa K, et al. The diagnostic dilemma of traumatic lumbar puncture: current standing of cerebrospinal fluid leukocyte corrections and our experience with cerebrospinal fluid biomarkers. J Child Neurol 2018; 33:441-448.
  5. Zhang G, Yang C, Kang X, Gao Z, Wan H, Liu Y. The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: a prospective study. Ann Clin Biochem 2018; doi: 10.1177/0004563218794729 (Epub ahead of print).
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