Carney complex (CNC)

Genetics

• This is a familial lentiginosis
• It is caused by mutations or deletions in the PRKAR1A gene on chromosome 17q
• The gene codes for type I alpha of protein kinase A (PKA)
• The transmission is autosomal dominant

Major tumours and lesions

Systemic adenomas

Other tumours

Skin and mucosal lesions

Previous designated acronyms: LAMB

References

1. Correa R, Salpea P, Stratakis CA. Carney complex: an update. Eur J Endocrinol 2015; 173:M85-M97. 
2. Stratakis CA. Carney complex: A familial lentiginosis predisposing to a variety of tumors. Rev Endocr Metab Disord 2016; 17:367-371. 

Related checklists

• Pituitary adenoma: clinical features
• Pituitary adenoma: management
• Other familial pituitary adenoma syndromes
• Pituitary apoplexy: clinical features
• Pituitary apoplexy: management