Brain tumours: risk factors
Evidence-based neurology checklist on brain tumours: risk factors: Genetic risk factors Tuberous sclerosis Neurofibromatosis 1 and 2 (NF1 and NF2) Neavoid basal cell carcinoma syndrome Adenomatous polyposis Folate metabolism gene polymorphisms: risk of meningiomas and gliomas SMARCB1/INI1 gene…
Genetic risk factors
- Tuberous sclerosis
- Neurofibromatosis 1 and 2 (NF1 and NF2)
- Neavoid basal cell carcinoma syndrome
- Adenomatous polyposis
- Folate metabolism gene polymorphisms: risk of meningiomas and gliomas
- SMARCB1/INI1 gene mutations
- L-2-hydroxyglutaric aciduria (L2HGDH) gene mutations
Chemical and environmental risk factors
Individual risk factors
Other risk factors
Mobile phone use
Factors which do not increase the risk of brain tumours
Factors which may reduce the risk of brain tumours
References
- Wigertz A, Lonn S, Mathiesen T, et al. Risk of brain tumors associated with exposure to exogenous female sex hormones. Am J Epidemiol 2006; 164:629-636.
- Wrensch M, Minn Y, Chew T, Bondy M, Berger MS. Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 2002; 4:278-299.
- Bethke L, Webb E, Murray A, et al. Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma. Cancer Epidemiol Biomarkers Prev 2008; 17:1195-1202.
- Zhang J, Zhou YW, Shi HP, Wang YZ, Li GL, Yu HT, Xie XY. 5,10-Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) gene polymorphisms and adult meningioma risk. J Neurooncol 2013; 115:233-239.
- Kohashi K, Oda Y. Oncogenic roles of SMARCB1/INI1 and its deficient tumors. Cancer Sci 2017; 108:547-552.
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