Behavioural variant frontotemporal dementia (bvFTD): pathology

Evidence-based neurology checklist on behavioural variant frontotemporal dementia (bvftd): pathology: Pathological variants FTD Tau: this shows tau aggregates FTD TDP: this shows TAR‐DNA‐binding protein‐43 (TDP‐43) aggregates FTD-FUS: this shows fused in sarcoma protein (FUS) aggregates FTD‐UPS:…

Pathological variants

  • FTD Tau: this shows tau aggregates 
  • FTD TDP: this shows TAR‐DNA‐binding protein‐43 (TDP‐43) aggregates
  • FTD-FUS: this shows fused in sarcoma protein (FUS) aggregates
  • FTD‐UPS: this shows ubiquitin-proteasome system

Pathological features

Serum features

References

  1. Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 2010; 24:375-398.
  2. Seelar H, Rohrer JD, Pijnenburg AL, Fox NC, van Swieten JC. Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review. JNNP 2011; 82:476-486.
  3. Neary D, Snowden J, Mann D. Frontotemporal dementia. Lancet Neurol 2005; 4:771-780.
  4. Boxer AL, Boeve BF. Frontotemporal dementia treatment: current symptomatic therapies and implications of recent genetic, biochemical, and neuroimaging studies. Alzheimer Dis Assoc Disord 2007; 21:S79-S87.
  5. Rosen HJ, Lengenfelder J, Miller B. Frontotemporal dementia. Neurol Clin. 2000; 18:979–992.
  6. And 7 more. Subscribe to see the full list

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