Autoimmune basal ganglia encephalitis (BGE)
Evidence-based neurology checklist on autoimmune basal ganglia encephalitis (bge): Causative antibodies Dopamine 2 receptor (D2R) antibody: this also causes Anti N-methyl-D-aspartate receptor (NMDAR) antibody Anti LGI1 Anti-recoverin antibodies (Abs) Seronegative Movement disorders Other…
Causative antibodies
- Dopamine 2 receptor (D2R) antibody: this also causes
- Anti N-methyl-D-aspartate receptor (NMDAR) antibody
- Anti LGI1
- Anti-recoverin antibodies (Abs)
- Seronegative
Movement disorders
Other neurological features
Psychiatric features
Magnetic resonance imaging (MRI) brain: features
Investigations
Differential diagnosis
Acute treatment
Chronic treatment
References
- Dale RC, Merheb V, Pillai S, et al. Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders. Brain 2012; 135:3453-3468.
- Dai X, Kuang L, Feng L, et al. Anti-dopamine receptor 2 antibody-positive encephalitis in adolescent. Front Neurol 2020; 11:471.
- Pawela C, Brunsdon RK, Williams TA, Porter M, Dale RC, Mohammad SS. The neuropsychological profile of children with basal ganglia encephalitis: a case series. Dev Med Child Neurol 2017; 59:445-448.
- Giri A, Andhale A, Acharya S, Kumar Singh R, Talwar D. Seronegative autoimmune basal ganglia encephalitis presenting as acute parkinsonism and refractory faciobrachial seizures: a case report. Cureus 2022; 14:e21351.
- Liu Y, Hao X, Zhou D, Hong Z. Relapsing and immune-responsive paroxysmal jaw clonus with blepharospasm and sialorrhea associated with D2R autoantibodies. Neurol Neuroimmunol Neuroinflamm 2022; 9:e1172.
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