Anti TNF-α neurological syndromes

Evidence-based neurology checklist on anti tnf-α neurological syndromes: TNFα inhibitor drugs Adalimumab Certolizumab Etanercept Golimumab Infliximab Central nervous system presentations Peripheral nervous system presentations Magnetic resonance imaging (MRI) features Cerebrospinal fluid (CSF)…

TNFα inhibitor drugs

  • Adalimumab
  • Certolizumab
  • Etanercept
  • Golimumab
  • Infliximab

Central nervous system presentations

Peripheral nervous system presentations

Magnetic resonance imaging (MRI) features

Cerebrospinal fluid (CSF) analysis

Neurophysiology

Treatment

References

  1. Ali F, Laughlin RS. Asymptomatic CNS demyelination related to TNF-α inhibitor therapy. Neurol Neuroimmunol Neuroinflamm 2016; 4:e298. 
  2. Seror R, Richez C, Sordet C, et al; Club Rhumatismes et Inflammation Section of the SFR. Pattern of demyelination occurring during anti-TNF-α therapy: a French national survey. Rheumatology (Oxford) 2013; 52:868-874. 
  3. Tejera-Segura B, Ferraz-Amaro I. Biological therapy and neurological manifestations. What do we know? Reumatol Clin 2016; pii: S1699-258X(16)30042-0 ([Epub ahead of print).
  4. Li SY, Birnbaum AD, Goldstein DA. Optic neuritis associated with adalimumab in the treatment of uveitis. Ocul Immunol Inflamm 2010; 18:475-481.
  5. Fockaert N, Goffin K, Demaerel P, Van Paesschen W. Infliximab-associated autoimmune limbic encephalitis: a case report. Acta Neurol Belg 2015; 115:161-163. 
  6. And 5 more. Subscribe to see the full list

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